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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2AK2 All Species: 10.3
Human Site: T88 Identified Species: 28.33
UniProt: P19525 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19525 NP_001129123.1 551 62094 T88 A V S P L L L T T T N S S E G
Chimpanzee Pan troglodytes NP_001138509 552 62233 T88 A V S P L V L T T T N S S E G
Rhesus Macaque Macaca mulatta NP_001077417 554 62134 T88 A V S P F S L T T T S S S E G
Dog Lupus familis XP_854775 1113 124420 F405 S V R I S E K F P T S P K A L
Cat Felis silvestris
Mouse Mus musculus Q03963 515 58261 E77 A V D I L D N E N K V D C H T
Rat Rattus norvegicus Q63184 513 58240 L74 A K L A V E I L D N E N K V D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989818 550 62328 S88 H T S D V V I S P L P A D V L
Frog Xenopus laevis NP_001091256 578 65027 V106 N T G S P S A V C I G E T E N
Zebra Danio Brachydanio rerio NP_001107942 682 77355 A201 L D R R S S V A D D S R S S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 80.5 21.1 N.A. 58.2 57.5 N.A. N.A. 38.1 34.7 29.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.2 87.7 33.3 N.A. 71.3 70.7 N.A. N.A. 56 55.1 45.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 80 13.3 N.A. 20 6.6 N.A. N.A. 6.6 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 86.6 26.6 N.A. 20 26.6 N.A. N.A. 40 13.3 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 56 0 0 12 0 0 12 12 0 0 0 12 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 0 0 0 12 0 0 % C
% Asp: 0 12 12 12 0 12 0 0 23 12 0 12 12 0 12 % D
% Glu: 0 0 0 0 0 23 0 12 0 0 12 12 0 45 0 % E
% Phe: 0 0 0 0 12 0 0 12 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 0 0 0 0 0 0 0 12 0 0 0 34 % G
% His: 12 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % H
% Ile: 0 0 0 23 0 0 23 0 0 12 0 0 0 0 0 % I
% Lys: 0 12 0 0 0 0 12 0 0 12 0 0 23 0 0 % K
% Leu: 12 0 12 0 34 12 34 12 0 12 0 0 0 0 23 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 0 0 0 0 0 12 0 12 12 23 12 0 0 12 % N
% Pro: 0 0 0 34 12 0 0 0 23 0 12 12 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 23 12 0 0 0 0 0 0 0 12 0 0 0 % R
% Ser: 12 0 45 12 23 34 0 12 0 0 34 34 45 12 0 % S
% Thr: 0 23 0 0 0 0 0 34 34 45 0 0 12 0 23 % T
% Val: 0 56 0 0 23 23 12 12 0 0 12 0 0 23 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _